Just Alex
Eminent member
- Joined
- Sep 21, 2015
- Posts
- 1,146
I know everyone knows about kratom, and most people know about kratom shots. But a new type of product has hit shelves, that of pure 7 hydroxymytragynine (7OH) and Mytragynine Psuedoindoxyl tablets. Both are metabolites of mytragynine, but in their pure form, they are very strong, and work very fast. Both are stronger than morphine, but the Psuedoindoxyl is said to be 14 times stronger than that of morphine, more than that of 7OH. Since I've discovered these, I don't want to use any other opioid because of how easy it is right now to acquire the tablets,how well they work, and their currently legality. They are getting popular, and it's probably just a matter of time before these attract the attention of the powers that be... I'm pretty concerned over that.
I'm Just mentioning it for those who can't for whatever reason acquire other strong narcotics. These work so very well. USPS has lost my psuedoindoxyl tablets, but hopefully they show up before I have to just say fuck it and order more. I've only had 7OH so far, as psuedo tabs are an even newer thing.
To be clear, 7OH is a partial agonist at the mu receptor, and an antagonist at delta and some others, but the Psuedoindoxyl is a FULL AGONIST at the mu receptor. Quality tabs can be purchased at kratomdistro.com That's not a plug, just one of the two places I have found that don't sell the branded more expensive tabs sold in smoke shops, these are pressed and supposedly come with labs.
From the webs:
7OH
7-Hydroxymitragynine, like mitragynine, appears to be a mixed opioid receptor agonist/antagonist, acting as a partial agonist at μ-opioid receptors and as a competitive antagonist at δ- and κ-opioid receptors.[8][9] Evidence suggests that 7-OH is more potent than both mitragynine and morphine. 7-OH does not activate the β-arrestin pathway like traditional opioids, meaning symptoms such as respiratory depression, constipation, and sedation are much less pronounced.[8]
7-OH is generated from mitragynine in vivo by hepatic metabolism and may account for a significant portion of the effects traditionally associated with mitragynine. Although 7-OH occurs naturally in kratom leaves, it does so in such low amounts that any ingested 7-OH is inconsequential compared to the 7-OH generated in the body.[8]
Mytragynine Psuedoindoxyl
Mitragynine pseudoindoxyl is a μ-opioid receptor agonist and δ-opioid receptor antagonist. It is a G protein biased agonist at the μ-opioid receptor, which may be responsible for its favorable side effect profile compared to conventional opioids.[3] Cryo-EM structures of μOR-Gi1 complex with mitragynine pseudoindoxyl and lofentanil (one of the most potent opioids) revealed that the two ligands engage distinct subpockets, and molecular dynamics simulations showed additional differences in the binding site that promote distinct active-state conformations on the intracellular side of the receptor where G proteins and β-arrestins bind.[4] Importantly, studies have shown that oxidative metabolism is capable of transforming mitragynine (the main alkaloid in kratom) into mitragynine pseudoindoxyl in two steps, which is likely to influence kratom's complex pharmacological effects.
I'm Just mentioning it for those who can't for whatever reason acquire other strong narcotics. These work so very well. USPS has lost my psuedoindoxyl tablets, but hopefully they show up before I have to just say fuck it and order more. I've only had 7OH so far, as psuedo tabs are an even newer thing.
To be clear, 7OH is a partial agonist at the mu receptor, and an antagonist at delta and some others, but the Psuedoindoxyl is a FULL AGONIST at the mu receptor. Quality tabs can be purchased at kratomdistro.com That's not a plug, just one of the two places I have found that don't sell the branded more expensive tabs sold in smoke shops, these are pressed and supposedly come with labs.
From the webs:
7OH
7-Hydroxymitragynine, like mitragynine, appears to be a mixed opioid receptor agonist/antagonist, acting as a partial agonist at μ-opioid receptors and as a competitive antagonist at δ- and κ-opioid receptors.[8][9] Evidence suggests that 7-OH is more potent than both mitragynine and morphine. 7-OH does not activate the β-arrestin pathway like traditional opioids, meaning symptoms such as respiratory depression, constipation, and sedation are much less pronounced.[8]
7-OH is generated from mitragynine in vivo by hepatic metabolism and may account for a significant portion of the effects traditionally associated with mitragynine. Although 7-OH occurs naturally in kratom leaves, it does so in such low amounts that any ingested 7-OH is inconsequential compared to the 7-OH generated in the body.[8]
Mytragynine Psuedoindoxyl
Mitragynine pseudoindoxyl is a μ-opioid receptor agonist and δ-opioid receptor antagonist. It is a G protein biased agonist at the μ-opioid receptor, which may be responsible for its favorable side effect profile compared to conventional opioids.[3] Cryo-EM structures of μOR-Gi1 complex with mitragynine pseudoindoxyl and lofentanil (one of the most potent opioids) revealed that the two ligands engage distinct subpockets, and molecular dynamics simulations showed additional differences in the binding site that promote distinct active-state conformations on the intracellular side of the receptor where G proteins and β-arrestins bind.[4] Importantly, studies have shown that oxidative metabolism is capable of transforming mitragynine (the main alkaloid in kratom) into mitragynine pseudoindoxyl in two steps, which is likely to influence kratom's complex pharmacological effects.
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