Memantine is the wonder chemical I’ve been searching for my whole life.

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Phancy

Phancy

Lapsed Senior Member
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Jun 12, 2022
Posts
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It’s helped with my depression and anxiety more than anything except maybe it’s as effective as cannabis. But it reduces opioid tolerance and amphetamine tolerance as well as prevents neurotoxicity. Your typical Nootropic source websites will have it. I can’t recommend it enough. Its an NMDA antagonist like ketamine and helps just as well for treatment resistant depression. It helps with my ADHD about half as well as my vyvanse script.
 
any idea what places have it in powder/pill form?I am new here and would love to tell your forum of what I had stoleen from an other website selling memantine
 
Ganesh said:
pinkflower said:
I'm puzzled by this because memantine is a prescribed medicine for dementia.
Click to expand...
Exactly, I’m also puzzled.
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Yes, it is prescribed for dementia and is a fairly new molecule but it’s been a life saver for me. I would share the source but I’m not sure if it’s against the rules? If you would like I can link to the research that has been done with regards to opioid tolerance etc
 
@Phancy Can I ask you some questions?
Does it need prescribing or can you buy it online?
Is it safe to take every day?
Any other information you think I might need would help also.
I am tapering off kratom, feel I have hit a wall at 20gpd, from 42gpd. I can't get substitute meds like methadone or sub.
I live in the uk and don't know bitcoin.
 
I would be cautious, here is what it says on wikipedia

Memantine is a medication used to slow the progression of moderate-to-severe Alzheimer's disease. It is taken by mouth. Common side effects include headache, constipation, sleepiness, and dizziness. Severe side effects may include blood clots, psychosis, and heart failure.
 
@Gullible
Gullible said:
I would be cautious, here is what it says on wikipedia

Memantine is a medication used to slow the progression of moderate-to-severe Alzheimer's disease. It is taken by mouth. Common side effects include headache, constipation, sleepiness, and dizziness. Severe side effects may include blood clots, psychosis, and heart failure.
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Thank you for your post.
 
jc776 said:
@Phancy Can I ask you some questions?
Does it need prescribing or can you buy it online?
Is it safe to take every day?
Any other information you think I might need would help also.
I am tapering off kratom, feel I have hit a wall at 20gpd, from 42gpd. I can't get substitute meds like methadone or sub.
I live in the uk and don't know bitcoin.
Click to expand...
You typically need to get it prescribed but you can find it online from nootropic vendors.
Safe to take everyday as far as I can tell. I looked through a lot of studies and meta-analysis and the amount of side effects is pretty minimal as well as any discontinuation symptoms. There are a few studies where it was given to people tapering from methadone or suboxone but I’m sure it’d be similar for a kratom taper. I take ~15mg a day. I don’t recommend abusing it but I tried 100mg and it felt like 10mg of 3-meo-pcp but it lasted for 40 hours. No problem for me since I love dissociatives but would probably be annoying to most people and I did get a slight headache indicating I was indeed misusing it. I just had to know for science. That being said the headspace it gets me in is very similar to the afterglow of ketamine where I feel like I understand my purpose in society and the steps that I need to take to be most effective, but it lasts and doesn’t go away
 
www.sciencedirect.com

The efficacy and tolerability of memantine for depressive symptoms in major mental diseases: A systematic review and updated meta-analysis of double-blind randomized controlled trials

To date, there is limited evidence on the antidepressant effects of memantine in patients with major mental diseases. We conducted a systematic review…
www.sciencedirect.com www.sciencedirect.com



www.sciencedirect.com

Adjunctive memantine for opioid use disorder treatment: A systematic review

Memantine is commonly used for the treatment of moderate-to-severe Alzheimer's disease. Due to its antagonism of the N-methyl-d-aspartate (NMDA) recep…
www.sciencedirect.com www.sciencedirect.com
 
Phancy said:
www.sciencedirect.com

The efficacy and tolerability of memantine for depressive symptoms in major mental diseases: A systematic review and updated meta-analysis of double-blind randomized controlled trials

To date, there is limited evidence on the antidepressant effects of memantine in patients with major mental diseases. We conducted a systematic review…
www.sciencedirect.com www.sciencedirect.com



www.sciencedirect.com

Adjunctive memantine for opioid use disorder treatment: A systematic review

Memantine is commonly used for the treatment of moderate-to-severe Alzheimer's disease. Due to its antagonism of the N-methyl-d-aspartate (NMDA) recep…
www.sciencedirect.com www.sciencedirect.com
Click to expand...
Hello and a big thank you.
 
pinkflower said:
I'm puzzled by this because memantine is a prescribed medicine for dementia.
Click to expand...
Not to be rude but it’s hard to believe people haven’t heard of medications being prescribed off label. Gabapentin was developed as an anti-epilepsy drug and now it’s prescribed for nerve pain. Amitryptaline is an antidepressant and now it’s prescribed for nerve pain. Hydroxychloroquine was developed as an anti-malaria drug and now it’s widely used as a first line immuno-suppressant for autoimmune diseases. Need we go on?

There is a growing list of medications I’m now looking at for off-label use for fibromyalgia, memantine is only one of them. AI is a big help (though not always compressive or unbiased, i.e. it might give one sided info based on the sources it scans, so use it as only one quick reference but keep searching and try rephrasing questions) finding info on off label uses. Perplexity AI, for instance, will tell you what use Memantine can be for fibromyalgia or ADHD patients.
 
My anti-depressant and anxyioltic is a nice dose of Lyrica. Like @BeeBonnet said, there are many medications that are used off label for different dispositions of diseases. Lyrica works on fibromyalgia and nerve pain (including anti--seizure properties) but is also approved for off label General Anxiety Disorder! It's a life saver for me, at least 😊
 
I’m interested in this Alzheimer’s drug. My grandmother and her mother died from Alzheimer’s. I know for certain I’ll get it. My memory has gotten worse and worse and I forgot where I was driving to the other day. I’m 42 but I wonder if a drug like that slows it even more at this age…
 
@Sunnysky444555 My dad is concerned about cognitive decline in his early 60s. I’m 43 myself. Use Perlexity.ai and ChatGPT to ask questions about various medications and follow up questions. Sometimes they give answers based on certain resources and you can tell them to find opposing evidence or to argue for or against if you want to get info that’s against the grain or not mainstream.

If you’re worried about Alzheimer’s, I’d also look into the role of animal fats in feeding the brain. Dr Elizabeth Bright is fantastic (if I have her name right), she advocates the carnivore diet. Which, btw, I’m not on. But my dad is and he says it saved his life. I want to get back to a meat heavy, low carb diet but not as low carb as keto. Ketosis gives me massive headaches that do not go away. But if you are concerned with cognitive decline, make sure your cooking with lard or butter, eating eggs with yolks, getting your animal fats, avoiding unnecessary vaccines, avoid regular use of antihistamines (if possible, I can’t survive without them) avoid mercury in fish like tuna, etc. Chicken liver pate is recommended, fish eggs, nutrient dense animal products. Check the Westin A Price foundation website for info on brain health and cognition.
 
I've tried memantine (it's sold OTC in my country). There is a thing about it that if you use a dosage that is high for you, the T1/2 is about 60 hours afaik, and you'll be in a limbo state for the whole week :)

But it certainly may give the sense of detachment, slight dissociative feeling (in therapeutic dosages) when nothing bothers you. The only thing that is really inconvenient is T 1/2, but that protects people from misusage, otherwise you might end up having a really bad week .

As far as I know people try to use it for different conditions, including depression, ADHD, anxiety and basically everything
 
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